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What medicines are available and are there natural alternatives?
Garlic/Allicin - 'Russian penicillin'
Complementary and alternative medicines
Specific HAIs/HCAIs
Probiotics
Medicinal products licensed by the MHRA for nosocomial infections or MRSA
Efficacy data from ZYVOX (linezolid) and details of side effects
Vancomycin and other antibiotics
Medical grade Manuka honey
Bee propolis - another 'Russian penicillin'
Silver wound dressings
Essential oils
Herbal medicines with safety information
Maggots/larval debridement
Bacteriophage/Free phages
Bacteriophage Efficacy data
Activated Oxygen/Medical Ozone
Bio-active copper textiles - antimicrobial face masks
Silver
Intravenous Vitamin C
Sunlight



 

Probiotics

News item - 5.11.06
Nutrition and bio-friendly microbes - simple answers to Clostridium difficile?

HCC/North Bucks Hospitals' new Action Plan:

"But oh dear, I think they have still completely overlooked the point about nutrition and the nutritional supplements as reported by the dieticians!!" DFW 2.11.06


pdfpdf: HCC Action Plan (180kb)


Help in preventing antibiotic-associated diarrhoea:

West Suffolk hospital's infection control team are going to try probiotics (friendly bacteria) as a £2000 pilot project.

news report - email a friend 29.10.06



to Immunity

gut flora
Photo: courtesy Prof. Glenn Gibson

"Dieticians said food supplements were not given" - a shortage of staff?
Healthcare Commission investigation p.47

"Four hundred and ninety eight patients were thought to have acquired C. difficile at Stoke Mandeville Hospital between April 2003 and March 2006 (as symptoms related to the infection developed after they had been in the hospital for at least 72 hours); 127 of these patients died."
Healthcare Commission investigation p.29

"It appears that the main defence against C. difficile infection is the
possession of normal bowel flora."

Department of Health and Public Health
Laboratory Service (1994).
Clostridium difficile infection: prevention and management: a report by the Joint DH/PHLS Working Group, page 7.


(1994)


"Should we be involved in similar work again, we will ensure we continue to include hydration and nutrition as part of the care of patients with C. difficile." 
Dr Heather Wood, Investigation Manager, Healthcare Commission, 3.10.06


Recent scientific paper: Summary
"Probiotics: their role in the treatment and prevention of disease"

Shira Doron and Sherwood L Gorbac
Expert Review of Anti-infective Therapy
April 2006, Vol. 4, No. 2, Pages 261-275


Slide show: Natural or alternative therapies for infectious diseases:
Lactobacilli in yoghurt reduce Clostridium Difficile associated diarrhoea and 'clear evidence that Saccharomyces boulardii is a useful adjunctive agent' concurrently with Vancomycin. A visual summary of probiotic therapy, phytomedicine (e.g. tea tree, garlic and cranberries) and bacteriophage therapy from Australia.
T.V.Riley 2003

Friendly bacteria:- medical trials collapse because probiotic Lactobacillus plantarum is so effective against Clostridium bacteria in small children with autism 5.9.06 to news item


Feedback
"Hi, Saw this in the paper.  I found it very interesting.  It made me think. It is not just antibiotics that knock the bacteria  in the gut out of balance - eg MMR vaccines etc. as well.  What if babies were given high doses of prebiotics and probiotics before and after vaccines? It would make them safer? Come to that, pregnant women should take them too as babies will pick up the Candida etc. from the mother and be born with weakened immune systems. All diseases start in the gut or as the saying goes 'Death starts in the gut'.

Angela G. Cooke
Holistic Health Alliance,
Reigate







Acknowledgments: thanks to Pearson & Black and Activated Oxygen for information and items in the picture.
Many holistic, environmentally friendly complementary and alternative medicines are in health food shops or via the internet - also preventative face masks, bio-active face masks and special dressings; natural olive oil with medical ozone; a steri-hardsurface disinfectant; essential oil blends of melaleuca, ravensara, sandalwood and other aromatic oils; pure essential oil synergistic mixes; homoeopathic remedies; natural botanical extract immuno-stimulator prior to surgery (Arnica 6 and Hypericum 6); colloidal silver; probiotics to boost the immune sysem; steri-hand and body creams and patient protection kits that may be of interest to relatives, hospital visitors and carers.

Phage therapy is available in some countries if you are able to travel. Contact us direct for
update and travel info - Sept 06.

Research material and other resources are generously donated to Designs For Wellbeing. Information about technologies that may help eradicate healthcare-associated infections is offered to the public free of charge at www.relax-well.co.uk and is not an advertisement or offered for sale or supply.
 
 



specific HAIs/HCAIs:



1. Urinary tract infection (Escherichia coli, Enterobacter)

2. Surgical site (or wound) infection (Staphylococcus aureus and MRSA)

3. Bacteraemia blood stream infection (Staphylococcus aureus and MRSA)

4. Antibiotic-associated diarrhoea/pseudomembranous colitis (Clostridium difficile)

5. Pneumonia (upper-respiratory flora)

6. MRSA colonisation or infection (MRSA e.g. epidemic strains 15 and 16)

7. Acinetobacter causing pneumonia

8. Vancomycin-resistant enterococci

9. Pseudomonas aeruginosa


 


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research by Designs For Wellbeing with an information scientist at the MHRA:


Pharmaceutical products


Fortum, Suprax, Zyvox,
Linezolid, Gabriox,
Bactroban, Amikin,
Netillin, Amikasin,
Tavanic, Meronem IV,
Oflocacin, Cefacor, Synercid IV
 
 
 
 

'The Lab'
bioscience image © courtesy Dr A.Tanczos, University of Surrey


Efficacy data from ZYVOX - see zyvox.com (healthcare professionals) for more info
linezolid %; vancomycin %
Full Prescribing Information for Zyvox
Warnings, Precautions, Adverse Reactions, Clinical Cure Rates




DFW: "What about the other antibiotics vancomycin, rifampicin, gentamicin, and linezolid? Are they authorised by the MHRA as licensed medicinal products?

MHRA: "Vancomycin is indicated in potentially life-threatening infections which cannot be treated with other effective, less toxic antimicrobial drugs, including the penicillins and cephalosporins.

"Vancomycin is useful in the therapy of severe staphylococcal infections in patients who cannot receive or who have failed to respond to the penicillins and cephalosporins, or who have infections with staphylococci resistant to other antibiotics.

"Vancomycin is used in the treatment of endocarditis and as prophylaxis against endocarditis in patients at risk from dental or surgical procedures.

" Its effectiveness has been documented in other infections due to staphylococci, including osteomyelitis, pneumonia, septicaemia and soft tissue infections. Vancomycin may be used orally for the treatment of staphylococcal enterocolitis and pseudomembranous colitis."



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DFW: "...thank you ... there is nothing on the list about Manuka honey dressings, or silver wound dressings, or essential oils. To the best of my knowledge, all these are now acceptable to the Dept of Health and NHS hospitals, community nurses (and of course holistic health practitioners and individuals around the world) - for treating patients with HCAIs and MRSA. These products are widely available.
So I thought it would be best to ask you first whether they were forgotten about when the list was being researched and prepared by the MHRA. Please could you let me know..."

26.08.05
MHRA: "Glad to be of help. I can only give you details of LICENSED medicinal products. The other products you mention are not licensed medicines."

19.09.05
MHRA: "The NHS uses many unlicensed products, but practitioners do so at their own risk. In the case of honey dressings, the risk is obviously low - unless the patient has a life-threatening infection."
Nov.05 Silver wound dressings and Medical Grade Manuka honey
dressings are 'CE' marked medical devices. More info


Names of herbal medicines with safety information

from MHRA


"The scientific literature indicates that essential oils can help control
healthcare-associated infections, including methicillin-resistant
staphylococcus aureus [MRSA]." Melanie Johnson Health Minister March 2005



Recommended reading:
The truth about tea tree: this includes a very simple recipe for you to make your own tea tree/shampoo/liquid soap/shower gel and prevent getting MRSA in the first place.

www.thetruthaboutteatree.com



3 scientific papers:

MRSA and essential oil.pdf

Manuka honey.pdf

Honey and pathogenic bacteria.pdf










Maggots
:



to maggots



MHRA: "Although maggots have been classified as 'medicinal products' there are currently no 'licensed maggots'. I believe those that are used in hospitals are produced as 'specials' under a special manufacturing licence for unlicensed medicines. Medicinal leeches are similarly classed as medicines but they aren't licensed."






Ref: A prescription for maggots: Jill Yesko.
Dr Ronald Serman's research could transform wound care and infection control.









Bacteriophage
:

Phage artwork courtesy Dr.A Tanczos
Phage© courtesy Dr.A.Tanczos, University of Surrey



DFW to MHRA: "Hopefully you could again help with this question - theoretically:
 
Now that primary wound dressings with active honey e.g. Activon Tulle are routinely prescribed on the NHS as medical devices, is it possible for primary wound dressings with active phages to also be on the list of medical devices?"


MHRA to DFW:
"In theory these would be either a medical device or a medicine in combination with a medical device.  This can only be determined when we receive full specifications and any claims made for the product from the manufacturer.  Whether the NHS would put it on their list is a matter for them to determine."

Special Licences: As with any unlicensed medicines in the UK, phage can be prescribed to a named patient by GPs and dentists who agree to take the responsibility with informed consent. We can provide the contact details for licensed wholesale dealers/importers.

Clinics in Poland, the Republic of Georgia and Texas welcome patients with various bacterial infections that no longer respond to antibiotics, and are successful with tens of thousands of patients and no harmful effects.

In Germany phage therapy is applied for individual cases of MRSA. Ref: Financial Times Germany



Free phages in food:

'Without knowing we constantly consume phages with our fermented food in yogurt (Brüssow et al., 1994),
sauerkraut (Lu et al., 2003b),
pickles (Lu et al., 2003a) or
salami (Chibani-Chennoufi et al., 2004c)'
Prof. T. H. Pennington

Ref:Phage Therapy: the Escherichia coli experience - Harald Bruessow

Protective effects were most pronounced in children younger than 3 years. Note, however, that this apparently well-designed study was documented in a 75-line publication written in Russian containing a single table (Babalova et al., 1968).' ..."

Graph - incidence per 1,000 children of diarrhoea comparing phage therapy with placebo


free phages? Questions to the MHRA 25.8.06


DFW: 1. Is it legally OK for someone to bring back to the UK a phage preparation for their own use or as a gift?


MHRA: Yes

DFW:2. Is it legally OK for people in the UK to be sent free samples of phage preparations (not necessarily for medical use but for food use - or simply educational purposes)?  

MHRA: Yes  - but probably not unsolicited mail shots which could be construed as advertising or promotion of the product.


summary - signposts to all our innovative phage therapy resources.


mini-review
- bacteriophage therapy ( pdf - 11 pages)

 


Bacteriophage efficacy data
from Polish Academy of Sciences
"highly effective" 85.9%





Activated oxygen/Medical Ozone




F.Fennell, Activated Oxygen Ltd.:

"We met a number of interesting people at the conference and exchanged information with them. Many infection control personnel were surprised to find our products and treatments as they had seldom considered Medical Ozone as an approach in treating patients. It is believed this has stimulated interest in further research into the field. We are planning to attend some universities in the near future to eradicate biofilms of various types in the laboratories."




Lord Colwyn:
"...There is no doubt that ozone therapy will play an increasingly important role in healthcare in the future. Now is not the time to explain how controlled exposure to minute amounts of ozone can immediately halt the process of dental decay and eliminate the use of the dental drill. The prospects for primary dental care are enormous."
Lords Hansard text for 30 April 2003




Bio-active copper textiles - antimicrobial face masks

see calendar for recent correspondence

"We are the bacterial warfare product."

"We're going to save a lot of lives."

Jeff Gabbay


Jeff with Hillary Clinton, US Senate, 2005

HCAI, MRSA etc.: "We have the same kind of thing that we've done for surgeons."

"Sheets that kill bacteria will go a long way towards solving the problem of infections acquired in hospitals."

Bird flu: "so the mask that we have will kill - actually destroy the virus when it comes in contact with it." "This is a mask that is going to cost almost the same as a normal mask." "This will be made for general distribution."
"
Skin infections: Bioactive copper socks are now standard issue for US Marines - "the rough and tough guys are wearing our socks" - "no smell".

This technology bonds copper compounds to fabrics, paper etc., therefore giving them powerful, long-lasting antimicrobial properties without causing any harm - e.g. clothing for surgeons, pyjamas, sheets.


to article at Israel21c

'Jerusalem News' article: Fighting germs with fabrics:



Silver






Keep ahead of germs with a silver coin in your water jug.
Check this out for facts about silver in modern medicine.
Read an interview about the disinfectant powers and non-toxic properties of colloidal silver.



Intravenous Vitamin C

photo courtesy of www.freeimages.co.uk






Sunlight


evidence









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